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Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. In particular, clot in the legs can cause thrombophlebitis and clot that travels to the lungs can cause sudden blocking of the vessel carrying blood to the lungs. Would you like to comment? Join The Doctor Channel for free account, or Login if you are already member. Agile is privately financed, with solid foundation for growth and backed by experienced healthcare investors, including ProQuest Investments, The Hillman Company, TL Ventures, and Novitas Capital. kob estradiol The reported endometrial cancer risk among unopposed estrogen users is about to 12-times greater than in nonusers, and appears dependent on duration of treatment and on estrogen dose.